Human papillomavirus, cervical carcinogenesis and chemoprevention with Indole derivates - a review of pathomechanisms

Rieck, Gudrun C. and Fiander, Alison Nina 2008. Human papillomavirus, cervical carcinogenesis and chemoprevention with Indole derivates - a review of pathomechanisms. Molecular Nutrition & Food Research 52 (1) , pp. 105-113. 10.1002/mnfr.200700138

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Abstract

Cervical cancer is the second most common female cancer worldwide with high risk Human Papillomavirus (HPV) infection playing an essential aetiological role. Oestrogen interacts with HPV at a cellular level causing cell growth and inhibition of apoptosis. Indole derivatives, formed during digestion of cruciferous vegetables, have been shown to have chemopreventative properties inhibiting HPV transcription and influencing oestrogen metabolism. This review describes the interactions between HPV, oestrogen and indole derivatives. Further clinical research is required to evaluate the chemopreventative properties of these agents.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords:	cervical cancer, chemoprevention, HPV, Indole derivates, oestrogen
Publisher:	Wiley
ISSN:	1613-4125
Last Modified:	31 Jan 2020 08:46
URI:	https://orca.cardiff.ac.uk/id/eprint/22927

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