Tris(8-hydroxyquinolinato)gallium(III)-loaded copolymer micelles as cytotoxic nanoconstructs for cosolvent-free organometallic drug delivery

Collins, Andrew M., Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, Ghiggi, Chiara, Hauser, Jonathan C., Burnett, Alan Kenneth and Mann, Stephen 2011. Tris(8-hydroxyquinolinato)gallium(III)-loaded copolymer micelles as cytotoxic nanoconstructs for cosolvent-free organometallic drug delivery. Small 7 (12) , pp. 1635-1640. 10.1002/smll.201100405

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Abstract

Therapeutically useful concentrations of the water-insoluble organometallic drug, tris(8-hydroxyquinolinato)gallium(III), are delivered to haematological cell lines without the need for toxic cosolvents. Delivery is by sequestration into aqueous micelles of a poly(ethylene glycol)/poly(propylene glycol)/poly(ethylene glycol) triblock copolymer using a facile method based on emulsion-mediated evaporation. The drug-loaded micelles function as a cell cycle inhibitor and cause cell death by a dose-dependent increase in apoptosis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	drug delivery; nanoconstructs; copolymers; cytotoxicity; anti-cancer agents
Publisher:	Wiley
ISSN:	1613-6810
Last Modified:	19 Oct 2022 10:01
URI:	https://orca.cardiff.ac.uk/id/eprint/22961

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