Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread

Schmid, Sonja, Metz, Philippe, Prat, Christine Marie Alexine, Gonzalez-Dunia, Daniel and Schwemmle, Martin 2010. Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread. Archives of Virology 155 (5) , pp. 789-793. 10.1007/s00705-010-0645-9

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Abstract

Mutational analysis of the phosphate acceptor sites of the Borna disease virus (BDV) phosphoprotein (P) has suggested a role of phosphorylation for viral spread. However, the studied mutant viruses also had two amino acid exchanges in the X protein, because the reading frames of P and X overlap. To determine the relative contribution of P and X to viral attenuation, we studied a P variant with serine-to-leucine substitutions (P(S26L,S28L)) in which the wild-type X sequence was conserved. Viral spread of rBDV-P(S26L,S28L) was impaired in human oligodendroglioma cells and in adult rats. Thus, BDV-P phosphorylation contributes to efficient viral dissemination.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Springer Verlag
ISSN:	0304-8608
Last Modified:	13 Oct 2016 16:00
URI:	https://orca.cardiff.ac.uk/id/eprint/23188

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