EAU guidelines on prostate cancer. Part I: screening, diagnosis, and treatment of clinically localised disease - Guía de la EAU sobre el cáncer de próstata. Parte I: cribado, diagnóstico y tratamiento del cáncer clínicamente localizado

Heidenreich, A., Bellmunt, J., Bolla, M., Joniau, S., Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869, Matveev, V., Mottet, N., Schmid, H. P., van der Kwast, T., Wiegel, T. and Zattoni, F. 2011. EAU guidelines on prostate cancer. Part I: screening, diagnosis, and treatment of clinically localised disease - Guía de la EAU sobre el cáncer de próstata. Parte I: cribado, diagnóstico y tratamiento del cáncer clínicamente localizado. Actas Urológicas Españolas 35 (9) , pp. 501-514. 10.1016/j.acuroe.2011.12.003

Full text not available from this repository.

Abstract

Objective: Our aim was to present a summary of the 2010 version of the European Association of Urology (EAU) guidelines on the screening, diagnosis, and treatment of clinically localised cancer of the prostate (PCa). Methods: The working panel performed a literature review of the new data emerging from 2007 to 2010. The guidelines were updated, and level of evidence and grade of recommendation were added to the text based on a systematic review of the literature, which included a search of online databases and bibliographic reviews. Results: A full version is available at the EAU office or Web site (www.uroweb.org). Current evidence is insufficient to warrant widespread population-based screening by prostate-specific antigen (PSA) for PCa. A systematic prostate biopsy under ultrasound guidance and local anaesthesia is the preferred diagnostic method. Active surveillance represents a viable option in men with low-risk PCa and a long life expectancy. PSA doubling time in < 3 yr or a biopsy progression indicates the need for active intervention. In men with locally advanced PCa in whom local therapy is not mandatory, watchful waiting (WW) is a treatment alternative to androgen-deprivation therapy (ADT) with equivalent oncologic efficacy. Active treatment is mostly recommended for patients with localised disease and a long life expectancy with radical prostatectomy (RP) shown to be superior to WW in a prospective randomised trial. Nervesparing RP represents the approach of choice in organ-confined disease; neoadjuvant androgen deprivation demonstrates no improvement of outcome variables. Radiation therapy should be performed with at least 74 Gy and 78 Gy in low-risk and intermediate/high-risk PCa, respectively. For locally advanced disease, adjuvant ADT for 3 yr results in superior disease-specific and overall survival rates and represents the treatment of choice. Follow-up after local therapy is largely based on PSA, and a disease-specific history with imaging is indicated only when symptoms occur. Conclusions: The knowledge in the field of PCa is rapidly changing. These EAU guidelines on PCa summarise the most recent findings and put them into clinical practice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	prostate cancer, EAU guidelines, review, diagnosis, treatment, follow-up, radical prostatectomy, radiation therapy, androgen deprivation
Publisher:	Elsevier
ISSN:	0210-4806
Last Modified:	19 Oct 2022 10:13
URI:	https://orca.cardiff.ac.uk/id/eprint/23642

Actions (repository staff only)

Edit Item