Endothelial response to childhood infection: The role of mannose-binding lectin (MBL)

Charakida, Marietta, Donald, Ann E., Leary, Sam, Halcox, Julian P. J., Turner, Malcolm W., Johnson, Marina, Loukogeorgakis, Stavros P., Okorie, Michael I., Smith, George Davey, Deanfield, John E. and Klein, Nigel J, 2010. Endothelial response to childhood infection: The role of mannose-binding lectin (MBL). Atherosclerosis 208 (1) , pp. 217-221. 10.1016/j.atherosclerosis.2009.07.055

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Abstract

OBJECTIVE: To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood. METHODS: We studied 2176 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. Endothelial function was assessed by flow mediated dilatation (FMD). Exon 1 and promoter polymorphisms in the MBL gene were determined by heteroduplexing procedures. Children were classified as AA (wild type) AO (heterozygotes) and OO (homozygotes). RESULTS: During the vascular assessment, 544 children presented with current or recent (<2 weeks) infection (INF). FMD was reduced in the INF group compared to controls (10% reduction in FMD, p<0.001). MBL genotype was not associated with FMD in controls, although a relationship with the degree of impairment during INF was observed (8.0%, 7.6% and 26.6% lower FMD compared to controls for groups AA, AO, OO respectively, p<0.05). After multivariate analysis, OO was associated with reduced FMD in the INF group (odds ratio 2.95 [1.33, 6.52], p<0.001). CONCLUSION: Homozygosity for MBL variant alleles is associated with greater impairment in FMD during infection in childhood. This suggests a gene-environment interaction operating in early life that may have relevance for the initiation and progression of atherosclerosis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Complement; Endothelium; Children; Genes; Mannose-binding lectin
Publisher:	Elsevier
ISSN:	0021-9150
Last Modified:	19 Mar 2016 22:40
URI:	https://orca.cardiff.ac.uk/id/eprint/23746

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