Highway to heaven: mammary gland development and differentiation

Melchor, Lorenzo and Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 2008. Highway to heaven: mammary gland development and differentiation. Breast Cancer Research 10 (5) , pp. 305-307. 10.1186/bcr2147

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Abstract

In recent years, the mammary gland epithelium has been shown to be a mixture of differentiated cell populations in a hierarchical relationship with their stem and progenitor cells. However, the mechanisms that regulate their cellular differentiation processes are still unclear. The identification of genes that govern stem and progenitor cell expansion, or that determine daughter cell fate, will be of crucial interest for understanding breast cancer diversity and, ultimately, improving treatment. Two recent analyses have identified some of the key genes that regulate these processes, lighting up the highway to normal mammary gland development.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > Q Science (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	BioMed Central
ISSN:	1465-5411
Date of First Compliant Deposit:	30 March 2016
Last Modified:	29 Jun 2023 08:34
URI:	https://orca.cardiff.ac.uk/id/eprint/24745

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