Gene conversion in evolution and disease

Chen, Jian-Min, Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484, Chuzhanova, Nadia, Férec, Claude and Patrinos, George P. 2009. Gene conversion in evolution and disease. Encyclopedia of Life Sciences, Chichester: John Wiley, (10.1002/9780470015902.a0005100.pub2)

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Abstract

Gene conversion involves the unidirectional transfer of genetic material from a ‘donor’ sequence to a highly homologous ‘acceptor’. Gene conversion is initiated by double-strand breaks and can arise from mutually exclusive pathways. Over evolutionary time, gene conversion has homogenized the paralogous sequences within each species whereas diversifying the orthologous sequences between closely related species; interallelic gene conversion has generated a high level of allelic diversity at certain loci. Not only has gene conversion played a key role in fashioning extant human genes but it has also been implicated as the molecular cause of an increasing number of human genetic diseases.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Uncontrolled Keywords:	gene conversion; cancer; concerted evolution; homologous recombination; human genetic disease
Publisher:	John Wiley
Related URLs:	Publisher
Last Modified:	19 Oct 2022 10:35
URI:	https://orca.cardiff.ac.uk/id/eprint/24867

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