Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Robinson, Matthew J., Osorio, Fabiola, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Freitas, Rui P., Schweighoffer, Edina, Gross, Olaf, Verbeek, J. Spief, Ruland, Jurgen, Tybulewicz, Victor, Brown, Gordon D., Moita, Luis Fereirra, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 and Reis e Sousa, Caetano 2009. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. Journal of Experimental Medicine 206 (9) , pp. 2037-2051. 10.1084/jem.20082818

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Abstract

Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi, have defined a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for inducing Th17 responses to fungal infection. We show that another C-type lectin, Dectin-2, also signals via Syk and CARD9, and contributes to dendritic cell (DC) activation by fungal particles. Unlike Dectin-1, Dectin-2 couples to Syk indirectly, through association with the FcRγ chain. In a model of Candida albicans infection, blockade of Dectin-2 did not affect innate immune resistance but abrogated Candida-specific T cell production of IL-17 and, in combination with the absence of Dectin-1, decreased Th1 responses to the organism. Thus, Dectin-2 constitutes a major fungal PRR that can couple to the Syk–CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0022-1007/ (accessed 12/03/2014).
Publisher:	Rockerfeller University Press
ISSN:	0022-1007
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 May 2023 02:39
URI:	https://orca.cardiff.ac.uk/id/eprint/24979

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