Toleman, Mark Alexander Howard  ORCID: https://orcid.org/0000-0002-9497-0512, Bennett, Peter M., Bennett, David M. C., Jones, Ronald N. and Walsh, Timothy Rutland ORCID: https://orcid.org/0000-0003-4315-4096
2007.
Global emergence of trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genes.
Emerging infectious diseases
13
, pp. 559-65.
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Abstract
Trimethoprim/sulfamethoxazole (TMP/SMX) resistance remains a serious threat in the treatment of Stenotrophomonas maltophilia infections. We analyzed an international collection of 55 S. maltophilia TMP/SMX-sensitive (S) (n=30) and -resistant (R) (n=25) strains for integrons; sul1, sul2 and dhfr genes; and insertion element common region (ISCR) elements. sul1, as part of a class 1 integron, was detected in 17 of 25 TMP/SMX-R. Nine TMP/SMX-R strains carried sul2; 7 were on large plasmids. Five TMP/SMX-R isolates were positive for ISCR2, and 4 were linked to sul2; 2 others possessed ISCR3. Two ISCR2s were adjacent to floR. Six TMP/SMX-S isolates harbored novel ISCR elements, ISCR9 and ISCR10. Linkage of ISCR3, ISCR9, and ISCR10 to sul2 and dhfr genes was not demonstrated. The data from this study indicate that class 1 integrons and ISCR elements linked to sul2 genes can mediate TMP/SMX resistance in S. maltophilia and are geographically widespread, findings that reinforce the need for ongoing resistance surveillance.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Medicine Systems Immunity Research Institute (SIURI) |
| Publisher: | National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC |
| ISSN: | 1080-6040 |
| Last Modified: | 17 Oct 2022 08:28 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/251 |
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