Novel regulation of PLCζ activity via its XY-linker

Nomikos, Michail ORCID: https://orcid.org/0000-0001-9761-6327, Elgmati, Khalil, Theodoridou, Maria, Georgilis, Athena, Gonzalez-Garcia, J. Raul, Nounesis, George, Swann, Karl ORCID: https://orcid.org/0000-0002-4355-1449 and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2011. Novel regulation of PLCζ activity via its XY-linker. Biochemical Journal 438 , pp. 427-432. 10.1042/BJ20110953

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Abstract

The XY-linker region of somatic cell PLC (phospholipase)-β, -γ, -δ and -ϵ isoforms confers potent catalytic inhibition, suggesting a common auto-regulatory role. Surprisingly, the sperm PLCζ XY-linker does not mediate auto-inhibition. Unlike for somatic PLCs, the absence of the PLCζ XY-linker significantly diminishes both in vitro PIP2 (phosphatidylinositol 4,5-bisphosphate) hydrolysis and in vivo Ca2+-oscillation-inducing activity, revealing evidence for a novel PLCζ enzymatic mechanism.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > RG Gynecology and obstetrics R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	calcium oscillation; egg activation; enzyme regulation; fertilization; phospholipase Cζ (PLCζ); XY-linker
Publisher:	Portland Press
ISSN:	0264-6021
Last Modified:	06 May 2023 20:22
URI:	https://orca.cardiff.ac.uk/id/eprint/25139

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