Wnt signalling in murine postnatal mammary gland development

Jarde, Thierry and Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963 2012. Wnt signalling in murine postnatal mammary gland development. Acta Physiologica 204 (1) , pp. 118-127. 10.1111/j.1748-1716.2011.02283.x

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Abstract

The mammary gland undergoes numerous developmental processes postnatally, from the elongation of the ductal tree-like structure to pregnancy-induced lobulo-alveolar development. Mammary epithelial stem cells have been suggested to be central to the control of enormous tissue expansion and remodelling during phases of mammary development. The Wnt signalling pathway plays a critical role in these biological steps and is suggested to be involved in the maintenance of the stem cell population. This review provides insight into recent findings on the activity of Wnt signalling during ductal and lobular mammary development and discusses the potential interplay between Wnt signals and mammary stem cells in mice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology
Uncontrolled Keywords:	breast; mammary gland; stem cells; Wnt pathway
Additional Information:	Special Issue: 19th Acta Physiologica international symposium ‘WNT Signaling in Physiology and Disease’
Publisher:	Scandinavian Physiological Society
ISSN:	1748-1708
Last Modified:	22 Jun 2023 10:01
URI:	https://orca.cardiff.ac.uk/id/eprint/25304

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