What community measurements can be used to predict bone disease in patients with COPD?

Bolton, Charlotte Emma, Cannings-John, Rebecca Louise ORCID: https://orcid.org/0000-0001-5235-6517, Edwards, Peter H., Ionescu, Andreea Alina, Evans, William D. ORCID: https://orcid.org/0000-0003-0013-8205, Pettit, Rebecca J., Faulkner, Trudy Ann, Stone, Michael D. and Shale, Dennis 2008. What community measurements can be used to predict bone disease in patients with COPD? Respiratory Medicine 102 (5) , pp. 651-657. 10.1016/j.rmed.2007.12.027

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Abstract

Background: Osteoporosis is common in patients with COPD. Previously we have reported that loss of fat-free mass (FFM), measured by dual X-ray absorptiometry (DXA) is associated with loss of bone mineral density (BMD). In addition, in patients with a low body mass index (BMI) and a low FFM, all had evidence of bone thinning, 50% having osteopenia and 50% osteoporosis. We explored the utility of different anthropometric measures in detecting osteoporosis in a community-based COPD population. Methods: Patients with confirmed COPD and not on long-term oral corticosteroids (n ¼ 58) performed spirometry. They underwent nutritional assessment by skinfold anthropometry, midarm circumference, calculation of both % ideal body weight (IBW) and BMI. All had DXA assessment of BMD. Results: A total of 58 COPD patients had anthropometric measurements taken, with a mean age of 66.8 (SD 8.7) years, 31 (58%) were male, with a forced expiratory volume in 1 s (FEV1) of 54.17 (20.18)% predicted. Osteoporosis was present at either the hip or lumbar region in 14 patients (24%). The useful anthropometric measurements identifying those with osteoporosis were both % IBW and BMI. The adjusted odds ratio for %IBW was 0.93 (95% confidence interval (CI) 0.87, 0.99), p ¼ 0.016 and for BMI: 0.79 (0.64–0.98), p ¼ 0.03. The receiver operating characteristics (ROC) score for both was 0.88, indicating a good fit. Conclusion: Osteoporosis is common, even in patients with mild airways obstruction. Nutritional assessment, incorporating a calculation of their BMI or %IBW may confer an additional benefit in detecting those at risk of osteoporosis and guide referral for BMD measurement.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Uncontrolled Keywords:	COPD; Osteoporosis; Body composition; Anthropometry
Publisher:	Elsevier
ISSN:	0954-6111
Last Modified:	05 Aug 2023 04:04
URI:	https://orca.cardiff.ac.uk/id/eprint/25419

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