Pulmonary function, body composition, and protein catabolism in adults with cystic fibrosis

Ionescu, Alina-Andrea, Nixon, Lisette Sheena ORCID: https://orcid.org/0000-0002-1270-6970, Luzio, Stephen Denis, Lewis-Jenkins, Vanessa, Evans, William D. ORCID: https://orcid.org/0000-0003-0013-8205, Stone, Michael D., Owens, David Raymond, Routledge, Philip Alexander and Shale, Dennis 2002. Pulmonary function, body composition, and protein catabolism in adults with cystic fibrosis. American journal of respiratory and critical care medicine 165 (4) , pp. 495-500.

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Abstract

Increased survival in cystic fibrosis (CF) is associated with bone thinning and fat-free mass (FFM) loss. We hypothesized that the severity of lung disease would be associated with increased protein catabolism and systemic inflammatory status in clinically stable patients. Forty adults with CF and 22 age-matched healthy subjects were studied. Body composition was determined by dual-energy X-ray absorptiometry. Urinary pseudouridine (PSU), a marker of protein breakdown, and cross-linked N-telopeptides of type I collagen (NTx), a marker of bone connective tissue breakdown, serum tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, and their soluble receptors were measured. A 3-d food intake diary revealed 21 patients had a low energy intake. Excretion of PSU (p = 0.019) and NTx (p < 0.01) was increased in patients and was inversely related to FEV1; PSU (r = - 0.53, p = 0.001) and NTx (r = - 0.43, p < 0.01). Increased excretion of PSU and NTx (p < 0.05 for both) was also related to a low FFM. All inflammatory mediators were greater in patients and were related to PSU and NTx. Clinically stable adults were catabolic with both cellular and connective tissue protein breakdown, which was related to lung disease severity, systemic inflammation, and body composition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Thoracic Society
ISSN:	1073-449X
Date of Acceptance:	3 December 2001
Last Modified:	01 Sep 2023 06:53
URI:	https://orca.cardiff.ac.uk/id/eprint/255

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