Loxoscelism: From basic research to the proposal of new therapies

Tambourgi, Denise V., Gonçalves-de-Andrade, Rute M. and Van Den Berg, Carmen Wilma 2010. Loxoscelism: From basic research to the proposal of new therapies. Toxicon 56 (7) , pp. 1113-1119. 10.1016/j.toxicon.2010.01.021

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Abstract

Loxoscelism is caused by envenomation by spiders from Loxosceles genus. Clinical symptoms only appear a few hours after envenomation and can evolve in local reactions, such as dermonecrosis, and systemic reactions, such as intravascular haemolysis, intravascular coagulation and renal failure. Current therapies are not effective, often not based in scientific research and can be even detrimental. A lack of understanding of the mechanism of action of the venom of the Loxosceles spider had thus far prevented development of effective therapies. In this review we aim to give an overview of our contributions to the understanding of the mechanism of action of the Loxosceles venom and propose targets and therapeutics for medical intervention.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Loxosceles spiders; Venom; Sphingomyelinase D (SMase D); Haemolysis; Complement system; Metalloproteinases; Dermonecrosis; Tetracyclines
Publisher:	Elsevier
ISSN:	0041-0101
Last Modified:	04 Jun 2017 03:44
URI:	https://orca.cardiff.ac.uk/id/eprint/25588

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