Withdrawal from familial ovarian cancer screening for surgery: Findings from a psychological evaluation study (PsyFOCS)

Lifford, Kate Joanna ORCID: https://orcid.org/0000-0002-9782-2080, Fraser, Lindsay, Rosenthal, Adam N., Rogers, Mark, Lancastle, Deborah, Phelps, Ceri, Watson, Eila K., Clements, Alison, Iredale, Rachel, Jacobs, Ian, Menon, Usha and Brain, Katherine Emma ORCID: https://orcid.org/0000-0001-9296-9748 2012. Withdrawal from familial ovarian cancer screening for surgery: Findings from a psychological evaluation study (PsyFOCS). Gynecologic Oncology 124 (1) , pp. 158-163. 10.1016/j.ygyno.2011.09.015

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Abstract

Objective A prospective psychological evaluation study of familial ovarian cancer screening (PsyFOCS) is underway in partnership with the UK Familial Ovarian Cancer Screening Study (UK FOCSS Phase 2). One of the aims of PsyFOCS is to examine factors associated with withdrawal from the UK FOCSS prior to the onset of 4-monthly screening. Method 1999 of 3224 women completed a baseline questionnaire. 110 (5.5%) women withdrew from screening prior to their first routine Phase 2 screen, of which 73 (66.4% of withdrawals) had withdrawn because they had undergone removal of their ovaries and fallopian tubes (withdrawn group). The comparison group consisted of 1868 women who remained on screening. The baseline questionnaire included measures of cancer-specific distress, anxiety, depression and illness perceptions. Results Logistic regression analysis indicated that having had prior annual (Phase 1) screening (OR = 13.34, p < .01), past experience of further tests (OR = 2.37, p < .01) and greater cancer-specific distress (OR = 1.38, p < .01) were associated with withdrawal for surgery. Belief in ageing as a cause of ovarian cancer was also associated with withdrawal (OR = 1.32, p = .05). Conclusion These cross-sectional data suggest that withdrawal from familial ovarian cancer screening may be influenced by both clinical and psychological factors. These may reflect women's experience of the drawbacks of screening and increased concern about ovarian cancer risk, as well as having opportunities to consider surgery as an alternative risk management strategy whilst using screening as an interim measure.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords:	Ovarian cancer ; Ovarian cancer screening ; Familial cancer ; Withdrawal from screening ; Cancer-specific distress ; Risk-reducing salpingo-oophorectomy
Publisher:	Elsevier
ISSN:	0090-8258
Last Modified:	10 Jun 2023 01:11
URI:	https://orca.cardiff.ac.uk/id/eprint/25695

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