Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population

Yosifova, Adelina, Mushiroda, Taisei, Stoianov, Drozdstoi, Vazharova, Radoslava, Dimova, Ivanka, Karachanak, Sena, Zaharieva, Irina, Milanova, Vihra, Madjirova, Nadejda, Gerdjikov, Ivan, Tolev, Todor, Velkova, Stoyanka, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Toncheva, Draga and Nakamura, Yusuke 2009. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Journal of Affective Disorders 117 (1-2) , pp. 87-97. 10.1016/j.jad.2008.12.021

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Abstract

Background Bipolar affective disorder (BAD) is a psychiatric illness characterized by episodes of mania and depression. Although the etiology is not clear, epidemiological studies suggest it is a result of an interaction of genetic and environmental factors. Despite of enormous efforts and abundant studies conducted, none has yet been identified definitively a gene susceptible to bipolar disorder. Methods Ninety-four Bulgarian patients diagnosed with bipolar disorder and 184 Bulgarian healthy individuals, were used for genotyping of 191 single nucleotide polymorphisms (SNPs) by TaqMan and/or Invader assays. Seventeen SNPs that revealed P value less than 0.05 in the first screening were genotyped using an additional independent set of samples, consisting of 78 BAD cases and 372 controls. Results After applying the Bonferonni correction on genotyping results of 172 cases and 556 controls, only one SNP, rs1800883, in the HTR5A gene revealed a significant level of P value (P = 0.000097; odds ratio = 1.80 (95%CI, 1.27–2.54); corrected P = 0.017). Conclusions Our findings suggest that HTR5A gene could play an important role in the pathogenesis of bipolar disorder in our population. However these findings should be viewed with caution and replication studies in other populations are necessary in support of these findings.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	bipolar affective disorder, case-control association study, single nucleotide polymorphism, candidate genes, invader assay, serotonin receptors
Publisher:	Elsevier
ISSN:	0165-0327
Last Modified:	19 Oct 2022 10:51
URI:	https://orca.cardiff.ac.uk/id/eprint/25741

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