Complement takes its Toll: an inflammatory crosstalk between Toll-like receptors and the receptors for the complement anaphylatoxin C5a

Holst, Benjamin, Raby, Anne-Catherine ORCID: https://orcid.org/0000-0002-5354-5835, Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 and Labeta, Mario Oscar ORCID: https://orcid.org/0000-0001-5750-6983 2012. Complement takes its Toll: an inflammatory crosstalk between Toll-like receptors and the receptors for the complement anaphylatoxin C5a. Anaesthesia 67 (1) , pp. 60-64. 10.1111/j.1365-2044.2011.07011.x

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Abstract

The innate immune system is responsible for a rapid inflammatory response to pathogens that is essential for the clearance of infections. Although this response is vital, it is nonetheless potentially harmful, and dysregulated inflammation is a feature of many disease states. Thus, the mechanisms that regulate the release of soluble mediators of inflammation are an active focus of investigation. The activation by infections of two key components of the innate immune system, the Toll-like receptors (TLRs) and complement, leading to the release of soluble mediators of inflammation, is critical to microbial killing and clearance. Both TLRs and complement are independently capable of triggering pro-inflammatory responses, but their synergistic interaction resulting from a substantial crosstalk markedly amplifies those responses and may contribute to the pathophysiology of diseases such as sepsis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RD Surgery R Medicine > RM Therapeutics. Pharmacology
Publisher:	Wiley
ISSN:	0003-2409
Last Modified:	04 Mar 2023 02:15
URI:	https://orca.cardiff.ac.uk/id/eprint/26120

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