Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry

Davies, R. Rhys, Scahill, Victoria L., Graham, Andrew, Williams, Guy B., Graham, Kim Samantha ORCID: https://orcid.org/0000-0002-1512-7667 and Hodges, John R. 2009. Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry. Neuroradiology 51 (8) , pp. 491-503. 10.1007/s00234-009-0521-z

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Abstract

We aimed to devise a rating method for key frontal and temporal brain regions validated against quantitative volumetric methods and applicable to a range of dementia syndromes. Four standardised coronal MR images from 36 subjects encompassing controls and cases with Alzheimer's disease (AD) and frontotemporal dementia (FTD) were used. After initial pilot studies, 15 regions produced good intra- and inter-rater reliability. We then validated the ratings against manual volumetry and voxel-based morphometry (VBM) and compared ratings across the subject groups. Validation against both manual volumetry (for both frontal and temporal lobes), and against whole brain VBM, showed good correlation with visual ratings for the majority of the brain regions. Comparison of rating scores across disease groups showed involvement of the anterior fusiform gyrus, anterior hippocampus and temporal pole in semantic dementia, while anterior cingulate and orbitofrontal regions were involved in behavioural variant FTD. This simple visual rating can be used as an alternative to highly technical methods of quantification, and may be superior when dealing with single cases or small groups.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Systems Immunity Research Institute (SIURI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Visual rating scale; MRI; VBM
Publisher:	Springer
ISSN:	0028-3940
Last Modified:	20 Oct 2022 07:44
URI:	https://orca.cardiff.ac.uk/id/eprint/26218

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