Interhemispheric hypoconnectivity in schizophrenia: fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives

Knöchel, Christian, Oertel-Knöchel, Viola, Schönmeyer, Ralf, Rotarska-Jagiela, Anna, van de Ven, Vincent, Prvulovic, David, Haenschel, Corinna, Uhlhaas, Peter, Pantel, Johannes, Hampel, Harald and Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292 2012. Interhemispheric hypoconnectivity in schizophrenia: fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives. NeuroImage 59 (2) , pp. 926-934. 10.1016/j.neuroimage.2011.07.088

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Abstract

Changes in hemispheric asymmetry and inter-hemispheric connectivity have been reported in schizophrenia. However, the genetic contribution to these alterations is still unclear. In the current study, we applied an automatic segmentation method to structural MRI and diffusion tensor imaging (DTI) data and examined volume and fiberintegrity of the corpuscallosum (CC), the main interhemisphericfiber tract, in 16 chronic schizophrenia (SZ) patients, matched first degree relatives and controls. SZ patients and relatives had smaller CC volumes than controls, particularly in the posterior genu, isthmus and splenium. Fractional anisotropy (FA), an indicator of fiberintegrity, was reduced in patients and relatives in the whole CC, the inferior genu, the superior genu and the isthmus. Correspondingly, the mean diffusivity (MD) values of the whole CC and the isthmus were higher in patients and their unaffectedrelatives, indicating decreased compactness and increased intercellular space. Relatives had intermediate values in the volumetric and fiberintegrity measurements between patients and controls. Lower CC volume and fiberintegrity in SZ patients were associated with more severe auditory hallucinations. These results support the connectivity hypothesis of SZ (Friston, 1998) and particularly highlight the altered interhemispheric connectivity, which appears to be a genetic feature of SZ risk.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Corpuscallosum; Schizophrenia; First-degree relatives; DTI; Volume
Publisher:	Elsevier
ISSN:	1053-8119
Last Modified:	20 Oct 2022 07:45
URI:	https://orca.cardiff.ac.uk/id/eprint/26269

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