Clinical characteristics of unipolar disorder and bipolar disorder according to the lifetime presence of recurrent panic attacks

Forty, Elizabeth, Smith, Daniel J., Jones, Lisa, Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Caesar, Sian, Cooper, Carly, Fraser, Christine, Gordon-Smith, Katherine, Hyde, Sally, Farmer, Anne, McGuffin, Peter and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2009. Clinical characteristics of unipolar disorder and bipolar disorder according to the lifetime presence of recurrent panic attacks. Bipolar Disorders 11 (3) , pp. 307-315. 10.1111/j.1399-5618.2009.00676.x

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Abstract

Objectives: The frequent comorbidity of panic and affective disorders has been described in previous studies. However, it is not clear how panic disorder comorbidity in unipolar disorder and bipolar disorder is related to illness course. Methods: We compared lifetime clinical characteristics of illness and items of symptomatology in samples of individuals with bipolar I disorder (n = 290) and unipolar disorder (n = 335) according to the lifetime presence of recurrent panic attacks. Results: We found significant differences in clinical course of illness characteristics that were shared across the unipolar and bipolar samples according to the lifetime presence of panic attacks. We also found a number of differences according to the presence of panic attacks that may be specific to the diagnostic group. Conclusions: Distinguishing patients who have mood disorder diagnoses, especially bipolar I disorder, according to the lifetime presence of panic attacks may not only be of use in clinical practice, but may also be informative for aetiological research, such as molecular genetic studies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	bipolar disorder, mood disorder, panic attacks, panic disorder, unipolar disorder
Publisher:	Wiley
ISSN:	1398-5647
Last Modified:	20 Oct 2022 07:49
URI:	https://orca.cardiff.ac.uk/id/eprint/26507

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