A longitudinal study of diffusion tensor MRI in ALS

Blain, Camilla R. V., Williams, Victoria C., Johnston, Clare, Stanton, Biba R., Ganesalingam, Jeban, Jarosz, Jozef M., Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Barker, Gareth J., Williams, Steve C. R., Leigh, Nigel P. and Simmons, Andy 2007. A longitudinal study of diffusion tensor MRI in ALS. Amyotrophic Lateral Sclerosis 8 (6) , pp. 348-355. 10.1080/17482960701548139

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Abstract

In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and whether changes in diffusion variables reflected clinical deterioration. Twenty‐three ALS patients and 25 healthy volunteers underwent whole brain DTI. Patients and a subset (n = 12) of controls returned for a second scan. Clinical measures of disease severity were assessed in the ALS group. Changes in fractional anisotropy (FA) and mean diffusivity (MD) were measured along the corticospinal tract using a region of interest approach. Adequate DTI data were available in 11 ALS patients and 11 controls at two time points. FA and MD differed significantly between ALS patients and controls at both time points, but neither changed significantly over time, while global measures of disease severity in patients increased with time. Although we confirmed that DTI detects corticospinal tract damage in ALS, there were no significant changes in diffusion measures over time. The sensitivity of DTI may be improved by advanced data analysis techniques, although the high dropout rate suggests that use of MRI as a biomarker in ALS may be restricted to earlier stages of disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Amyotrophic lateral sclerosis, longitudinal, diffusion tensor MRI, corticospinal tract
Publisher:	Informa Healthcare
ISSN:	1748-2968
Last Modified:	20 Oct 2022 07:51
URI:	https://orca.cardiff.ac.uk/id/eprint/26630

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