Decreased Gray Matter Concentration in the Lateral Geniculate Nuclei in Human Amblyopes

Barnes, G. R., Li, X., Thompson, B., Singh, Krish Devi ORCID: https://orcid.org/0000-0002-3094-2475, Dumoulin, S. O. and Hess, R. F. 2010. Decreased Gray Matter Concentration in the Lateral Geniculate Nuclei in Human Amblyopes. Investigative Ophthalmology & Visual Science 51 (3) , pp. 1432-1438. 10.1167/iovs.09-3931

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Abstract

Purpose. In a group of humans with strabismic amblyopia, the relationship was examined between the structure and function of different brain regions. Three question were addressed: (1) Is the lateral geniculate nucleus (LGN) in humans with amblyopia structurally as well as functionally abnormal? (2) Do structural anomalies in the visual cortex correlate with the previously reported cortical functional losses? (3) Is there a link between the functional anomalies in the visual cortex and any structural anomalies in the geniculate? Methods. The structure was compared by using voxel-based morphometry (VBM) and the function by functional magnetic resonance imaging (fMRI). Results. The results showed that the geniculate is structurally abnormal in humans with strabismic amblyopia. Conclusions. These findings add further weight to the role of the LGN in the cortical deficits exhibited in human strabismic amblyopes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	Confirmation received by publisher on 21 February 2014 that publisher's pdf can be self-archived 6 months after publication.
Publisher:	Association for Research in Vision and Ophthalmology
ISSN:	0146-0404
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 May 2023 01:45
URI:	https://orca.cardiff.ac.uk/id/eprint/26723

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