Functional neuroanatomy supporting judgments of when events occurred

Greve, Andrea, Doidge, Amie N., Evans, Christopher John ORCID: https://orcid.org/0000-0002-6619-4245 and Wilding, Edward Lewis ORCID: https://orcid.org/0000-0002-9495-1418 2010. Functional neuroanatomy supporting judgments of when events occurred. The Journal of Neuroscience 30 (20) , pp. 7099-7104. 10.1523/JNEUROSCI.0345-10.2010

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Abstract

The neural substrates of memory for when events occurred are not well described. One reason for this is that the paradigms used to date have permitted isolation of only some of the relevant memory processes. In this experiment, functional magnetic resonance imaging was used to identify for the first time brain regions that support two distinct bases upon which “when” judgments can be made. Seventeen human participants (6 male) completed a continuous recognition memory task where the interval between presentation and re-presentation of words varied between 5 and 25 intervening words (the lag). The task on each trial was to distinguish repeated words from those presented for the first time, and to indicate the lag for repeated words. The inferior parietal lobe showed greater activation for shorter lag judgments, regardless of judgment accuracy. The lingual gyrus, by contrast, was more active for correct than for incorrect lag judgments, regardless of the interval between first and second item presentations. Both of these regions have been linked in previous work to the process of recollection, and the findings described here represent a novel neural dissociation across regions that deploy mnemonic information in fundamentally different ways to support judgments about when events occurred.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date of First Compliant Deposit:	30 March 2016
Last Modified:	11 May 2023 01:13
URI:	https://orca.cardiff.ac.uk/id/eprint/26736

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