Modeling the contribution of neuron-astrocyte cross talk to slow blood oxygenation level-dependent signal oscillations

DiNuzzo, M., Gili, Tommaso ORCID: https://orcid.org/0000-0001-9154-1758, Maraviglia, B. and Giove, F. 2011. Modeling the contribution of neuron-astrocyte cross talk to slow blood oxygenation level-dependent signal oscillations. Journal of Neurophysiology 106 (6) , pp. 3010-3018. 10.1152/jn.00416.2011

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Abstract

A consistent and prominent feature of brain functional magnetic resonance imaging (fMRI) data is the presence of low-frequency (<0.1 Hz) fluctuations of the blood oxygenation level-dependent (BOLD) signal that are thought to reflect spontaneous neuronal activity. In this report we provide modeling evidence that cyclic physiological activation of astroglial cells produces similar BOLD oscillations through a mechanism mediated by intracellular Ca2+ signaling. Specifically, neurotransmission induces pulses of Ca2+ concentration in astrocytes, resulting in increased cerebral perfusion and neuroactive transmitter release by these cells (i.e., gliotransmission), which in turn stimulates neuronal activity. Noticeably, the level of neuron-astrocyte cross talk regulates the periodic behavior of the Ca2+ wave-induced BOLD fluctuations. Our results suggest that the spontaneous ongoing activity of neuroglial networks is a potential source of the observed slow fMRI signal oscillations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	astrocytes; calcium waves; brain resting state
Publisher:	American Physiological Society
ISSN:	0022-3077
Last Modified:	20 Oct 2022 07:52
URI:	https://orca.cardiff.ac.uk/id/eprint/26762

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