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CD25+ regulatory cells uncover immune responses to shared tumour rejection antigens

Golgher, Denise, Jones, Emma, Powrie, Fiona, Elliot, Tim and Gallimore, Awen Myfanwy ORCID: 2002. CD25+ regulatory cells uncover immune responses to shared tumour rejection antigens. European Journal of Immunology 32 (11) , pp. 3267-3275. 10.1002/1521-4141(200211)32:11<3267::AID-IMMU3267>3.0.CO;2-1

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Although it is known that the immune system can mount responses to a variety of tumors it is clear that most tumors exhibit weak or even undetectable immunogenicity. Recent findings suggest that the lack of tumor immunogenicity is partly due to a population of cells called CD4+CD25+ regulatory T cells since depletion of these cells in mice can result in tumor rejection.These cells have also been shown to inhibit the development of organ-specific autoimmune diseases suggesting that they inhibit immune responses to tissue-specific self-antigens. Such immune responses may also mediate tumor rejection. Alternatively, immune responses in mice depleted of regulatory cells may target tumor antigens that are not tissue-specific, but which are shared by tumors of diverse origins. In experiments performed to discriminate between these possibilities we found, using the murine colorectal tumor CT26, that tumor immunity stimulated in the absence of regulatory cells is not restricted to tumors of colorectal origin, but is effective against tumors of different histological types such as B cell lymphomas and a renal cell carcinoma. By comparing this to CT26-induced immunity through the use of adjuvant we show that the generation of cross-reactive tumor immunity is a specific manifestation of CD25+ regulatory cell depletion. The generation of CD4+T cells capable of mediating tumor rejection is another important feature of tumor immunity induced in the absence of CD25+ cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Uncontrolled Keywords: Tumor immunity; Shared antigen; Regulatory T cell; CT26
Publisher: John Wiley & Sons
ISSN: 15214141
Last Modified: 17 Oct 2022 08:29

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