Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins

Wootton, M., Walsh, Timothy Rutland ORCID: https://orcid.org/0000-0003-4315-4096, Macfarlane, L. and Howe, R. A. 2010. Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins. Journal of Antimicrobial Chemotherapy 65 (1) , pp. 79-81. 10.1093/jac/dkp404

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Abstract

Objectives To assess the activity of mecillinam against two groups of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined β-lactamases; and (ii) isolates resistant to third-generation cephalosporins referred from across Wales. Methods Antibiotic susceptibility testing with mecillinam, meropenem, amoxicillin, co-amoxiclav, cefotaxime, piperacillin/tazobactam, ciprofloxacin, nitrofurantoin, trimethoprim and gentamicin was performed using the BSAC agar dilution method against 30 international strains of E. coli with known β-lactamase presence. Antibiotic susceptibility testing with mecillinam using the same method was performed against 325 regional isolates of E. coli resistant to third-generation cephalosporins. Results The susceptibility results showed that the only antibiotics to which the 30 international isolates were consistently susceptible were mecillinam (100%) and meropenem (100%), irrespective of the presence of β-lactamases. Of the local isolates, 93.5% (304/325) were susceptible to mecillinam, having MICs < 8 mg/L. Conclusions Our results show that mecillinam has excellent in vitro activity against a range of E. coli exhibiting β-lactamase activity, some with the production of multiple β-lactamases. It is time to further evaluate the clinical utility of mecillinam in the treatment of infections caused by such organisms.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords:	ESBLs, susceptibilities, resistance
Publisher:	Oxford University Press
ISSN:	0305-7453
Last Modified:	20 Oct 2022 07:54
URI:	https://orca.cardiff.ac.uk/id/eprint/26865

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