Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis

Thomas, K., Rafiq, S., Frayling, T. M., Ebrahim, S., Kumari, M., Gallacher, John Edward ORCID: https://orcid.org/0000-0002-2394-5299, Ferrucci, L., Bandinelli, S., Wallace, R. B., Melzer, D., Martin, R. M. and Ben-Shlomo, Y. 2009. Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 64A (11) , pp. 1177-1182. 10.1093/gerona/glp092

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Abstract

Background Levels of the proinflammatory cytokine interleukin-18 (IL-18) are raised in old age and are associated with reduced physical functioning. Previous studies have indicated that the C allele of the rs5744256 polymorphism in the IL-18 gene is strongly associated with reduced circulating IL-18 levels. This variant has previously been associated with improved locomotor performance in old age, but the finding requires independent replication. Methods We examined the association between the IL-18 polymorphism rs5744256 and physical functioning in three cohorts with a total of 4,107 participants aged 60–85 years: the English Longitudinal Study of Ageing, Caerphilly, and Boyd Orr. We meta-analyzed (N = 6,141) the results with data from the original paper reporting this association: Iowa-Established Populations for Epidemiological Study of the Elderly and InCHIANTI cohorts. Physical functioning was assessed by timed walks or the get up and go test. As locomotor performance tests differed between the cohorts and the distributions of times to complete the test (in seconds) were positively skewed, we used the reciprocal transformation and computed study-specific z scores. Results Based on the three new studies, the estimated linear regression coefficient per C allele was 0.011 (95% confidence interval [95% CI]: −0.04 to 0.06). A meta-analysis that pooled the data from all studies showed weak evidence of an effect, with a regression coefficient of 0.047 (95% CI: 0.010 to 0.083). Conclusions We did not replicate an association between the IL-18 rs5744256 polymorphism and the physical function in people aged 60–85 years. However, pooling data from all studies suggested a weak association of the C allele of the rs5744256 single nucleotide polymorphism on improving walking times in old age.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Interleukin-18; polymorphism; IL-18; ageing; physical function; gait speed; walk time
Publisher:	Oxford Journals
ISSN:	1079-5006
Last Modified:	20 Oct 2022 08:10
URI:	https://orca.cardiff.ac.uk/id/eprint/27454

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