Amygdala protein kinase C epsilon controls alcohol consumption

Lesscher, H. M. B., Wallace, Melisa Joellan, Zeng, L., Wang, V., Deitchman, J. K., McMahon, T., Messing, R. O. and Newton, P. 2009. Amygdala protein kinase C epsilon controls alcohol consumption. Genes, Brain and Behavior 8 (5) , pp. 493-499. 10.1111/j.1601-183X.2009.00485.x

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Abstract

Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCe) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCe signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCe in the amygdala reduced ethanol consumption and preference in a limited-access paradigm. Further, mice that are heterozygous for the PKCe allele consume less ethanol compared with wildtype mice in this paradigm. These mice have a >50% reduction in the abundance of PKCe in the amygdala compared with wild-type mice. We conclude that amygdala PKCe is important for ethanol consumption in mice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Alcohol; amygdala; limited access paradigm; RNA interference; protein kinase C epsilon; mice
Publisher:	Blackwell Publishing
ISSN:	1601-1848
Last Modified:	04 May 2016 02:14
URI:	https://orca.cardiff.ac.uk/id/eprint/27656

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