Does broad-spectrum β-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?

Nordmann, Patrice, Poirel, Laurent, Toleman, Mark Alexander Howard ORCID: https://orcid.org/0000-0002-9497-0512 and Walsh, Timothy Rutland ORCID: https://orcid.org/0000-0003-4315-4096 2011. Does broad-spectrum β-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria? Journal of Antimicrobial Chemotherapy 66 (4) , pp. 689-692. 10.1093/jac/dkq520

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Abstract

The NDM-1 gene, first identified in Sweden in 2008 in Klebsiella pneumoniae from a patient hospitalized in New Delhi, encodes a metallo-β-lactamase that inactivates all β-lactams except aztreonam. This blaNDM-1 gene has been identified in hospital-acquired bacterial species, such as K. pneumoniae, but also in the typical community-acquired species, Escherichia coli. This gene has been identified in strains that possess other resistance mechanisms contributing to their multidrug resistance patterns. It has been recently extensively reported from the UK, India and Pakistan and, albeit to a lesser extent, from a number of other countries worldwide. In most of the cases a link with the Indian subcontinent has also been established. To stem the onslaught of NDM producers, early identification of cases of NDM-related infections and prevention of their spread by implementing screening, hygiene measures and the isolation of carriers is needed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine
Uncontrolled Keywords:	Metallo-β-lactamases ; Carbapenemases ; Enterobacteriaceae ; India Pakistan
Publisher:	Oxford University Press
ISSN:	0305-7453
Last Modified:	20 Oct 2022 08:14
URI:	https://orca.cardiff.ac.uk/id/eprint/27672

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