Clinical differences between bipolar and unipolar depression

Forty, Elizabeth, Smith, D., Jones, L., Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Caesar, S., Cooper, C., Fraser, Christine, Gordon-Smith, K., Hyde, S., Farmer, A., McGuffin, P. and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2008. Clinical differences between bipolar and unipolar depression. The British Journal of Psychiatry 192 (5) , pp. 388-389. 10.1192/bjp.bp.107.045294

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Abstract

It is commonly – but wrongly – assumed that there are no important differences between the clinical presentations of major depressive disorder and bipolar depression. Here we compare clinical course variables and depressive symptom profiles in a large sample of individuals with major depressive disorder (n=593) and bipolar disorder (n=443). Clinical characteristics associated with a bipolar course included the presence of psychosis, diurnal mood variation and hypersomnia during depressive episodes, and a greater number of shorter depressive episodes. Such features should alert a clinician to a possible bipolar course. This is important because optimal management is not the same for bipolar and unipolar depression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	20 Oct 2022 08:29
URI:	https://orca.cardiff.ac.uk/id/eprint/28504

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