Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS)

Gallacher, John Edward ORCID: https://orcid.org/0000-0002-2394-5299, Elwood, Peter Creighton, Pickering, Janet Elizabeth, Bayer, Antony James ORCID: https://orcid.org/0000-0002-7514-248X, Fish, Mark and Ben-Shlomo, Yoav 2012. Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS). Journal of Epidemiology and Community Health 66 (10) , pp. 869-873. 10.1136/jech-2011-200314

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Abstract

Background Benzodiazepine use is widespread in older people, although its benefit is uncertain. Aim To investigate the long-term effect of benzodiazepine use upon dementia risk. Methods A prospective cohort of men seen on five occasions over 22 years with full medication histories, repeat measures of cognitive function and a clinical diagnosis of dementia. Results Of 1134 men with complete data, 103 (9.1%) had been taking benzodiazepines regularly at one or more phases. These men showed a marked increased incidence of dementia (OR¼3.50, 95% CI 1.57 to 7.79, p¼0.002), which persisted despite adjustment for psychological distress and other covariates. Men exposed in earlier phases showed a greater association than more recent exposure, counter to what one would expect if this was due to reverse causation, though we failed to demonstrate a doseeresponse effect with drug duration. Conclusion The taking of benzodiazepines is associated with an increased risk of dementia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine
Publisher:	BMJ Group
ISSN:	0143-005X
Last Modified:	10 Jun 2023 01:14
URI:	https://orca.cardiff.ac.uk/id/eprint/28821

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