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Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS)

Gallacher, John Edward ORCID:, Elwood, Peter Creighton, Pickering, Janet Elizabeth, Bayer, Antony James ORCID:, Fish, Mark and Ben-Shlomo, Yoav 2012. Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS). Journal of Epidemiology and Community Health 66 (10) , pp. 869-873. 10.1136/jech-2011-200314

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Background Benzodiazepine use is widespread in older people, although its benefit is uncertain. Aim To investigate the long-term effect of benzodiazepine use upon dementia risk. Methods A prospective cohort of men seen on five occasions over 22 years with full medication histories, repeat measures of cognitive function and a clinical diagnosis of dementia. Results Of 1134 men with complete data, 103 (9.1%) had been taking benzodiazepines regularly at one or more phases. These men showed a marked increased incidence of dementia (OR¼3.50, 95% CI 1.57 to 7.79, p¼0.002), which persisted despite adjustment for psychological distress and other covariates. Men exposed in earlier phases showed a greater association than more recent exposure, counter to what one would expect if this was due to reverse causation, though we failed to demonstrate a doseeresponse effect with drug duration. Conclusion The taking of benzodiazepines is associated with an increased risk of dementia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Publisher: BMJ Group
ISSN: 0143-005X
Last Modified: 10 Jun 2023 01:14

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