Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents

Matthews, Ian Price, Henderson, Katrina A., Gregory, Clive James ORCID: https://orcid.org/0000-0003-4876-3982, Palmer, Stephen Royston and Lang, Derek 2010. Effects of emissions from different type of residential heating upon cyclic guanosine monophosphate (cGMP) in blood platelets of residents. Biomarkers 15 (1) , pp. 86-93. 10.3109/13547500903311894

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Abstract

We hypothesized that different types of residential heating would be associated with different levels of indoor carbon monoxide (CO) and further that this might result in a differential in the concentration of cyclic 3′:5′ guanosine monophosphate (cGMP) in blood platelets in exposed residents. Individuals, who were recruited from homes using different fuel for heating, donated a venous blood sample in the winter and in the summer. In the winter the median blood platelet cGMP value for the group using liquid propane gas (LPG) was 65% higher than for the group using piped natural gas for heating (p <0.001). Also in the group using LPG, the median concentration of cGMP in the winter was 39% higher than the summer median (p < 0.003). The mean indoor concentrations of CO were measured over a period of 1 week during the winter and were <1 ppm. We conclude that observed differences were associated with emissions from different types of heating but that CO exposure alone is too low to explain these.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	carbon monoxide, cyclic guanosine monophosphate, blood platelets
Publisher:	Informa Healthcare
ISSN:	1354-750X
Last Modified:	06 Nov 2022 14:13
URI:	https://orca.cardiff.ac.uk/id/eprint/28962

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