Molecular genetics and the kraepelinian dichotomy: one disorder, two disorders, or do we need to start thinking afresh?

Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2010. Molecular genetics and the kraepelinian dichotomy: one disorder, two disorders, or do we need to start thinking afresh? Psychiatric Annals 40 (2) , pp. 88-91. 10.3928/00485718-20100127-04

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Abstract

The Kraepelinian dichotomy — the broad division of the major mood and psychotic illnesses of adulthood into schizophrenia and manic depressive illness — has been enshrined in Western psychiatry for more than a century and continues to influence clinical practice, research, and public perceptions of mental illness. Although cogent arguments for abandoning an essentially dichotomous approach in favor of alternative formulations (categorical, dimensional, or continuous) have often been advanced, these have failed to gain widespread support, in part because of lack of robust scientific data, but possibly also because of the practical complexity of applying alternative classifications in clinical practice and research settings.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Healio
ISSN:	0048-5713
Last Modified:	20 Oct 2022 08:47
URI:	https://orca.cardiff.ac.uk/id/eprint/29583

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