Differential constrictor responses of cephalic and caudal vasculature to α-adrenoceptor agonist after hind limb unloading

Hutchings, Simon R, Kim, Jong Moo, Song, Dongzhe and Pang, Catherine C. Y. 2010. Differential constrictor responses of cephalic and caudal vasculature to α-adrenoceptor agonist after hind limb unloading. Canadian Journal of Physiology and Pharmacology 88 (11) , pp. 1035-1041. 10.1139/Y10-083

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Abstract

We examined the effects of hind limb unloading (HLU, 14 days) on constriction of carotid and iliac arterial beds in vivo in thiobutabarbital-anaesthetized rats and isolated carotid and iliac arteries in vitro. Both control and HLU rats had similar arterial pressure and carotid and iliac arterial flows. The HLU rats had increased carotid arterial but reduced iliac arterial constriction in response to methoxamine (α1-adrenoceptor agonist) in vivo. In contrast, constriction in response to methoxamine was reduced in the isolated carotid and unchanged in the iliac artery of HLU rats relative to control rats. Thus, HLU is associated with increased constriction of carotid arterial bed but reduced constriction of the isolated carotid artery, and reduced constriction of iliac arterial bed but unchanged constriction of the isolated iliac artery. These results show differential influence of HLU on constriction of cephalic and caudal arterial beds, and differential effect on constrictions of arterial beds relative to conduit arteries.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	adrenoceptor; autoregulation; lower body negative pressure; simulated microgravity; vascular blood flow; vasoconstriction; methoxamine; hind limb unweighting
Publisher:	NRC Research Press
ISSN:	0008-4212
Last Modified:	19 Mar 2016 22:52
URI:	https://orca.cardiff.ac.uk/id/eprint/29770

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