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Identification of loci associated with schizophrenia by genome-wide association and follow-up

O'Donovan, Michael Conlon ORCID:, Craddock, Nicholas John ORCID:, Norton, Nadine ORCID:, Williams, Hywel John ORCID:, Peirce, Timothy Rowan, Escott-Price, Valentina ORCID:, Nikolov, Ivan, Hamshere, Marian Lindsay ORCID:, Carroll, Liam Stuart, Georgieva, Lyudmila, Dwyer, Sarah Lynne, Holmans, Peter Alan ORCID:, Marchini, Jonathan L, Spencer, Chris C A, Howie, Bryan, Leung, Hin-Tak, Hartmann, Annette M, Möller, Hans-Jürgen, Morris, Derek W, Shi, YongYong, Feng, GuoYin, Hoffmann, Per, Propping, Peter, Vasilescu, Catalina, Maier, Wolfgang, Rietschel, Marcella, Zammit, Stanley ORCID:, Schumacher, Johannes, Quinn, Emma M, Schulze, Thomas G, Williams, Nigel Melville ORCID:, Giegling, Ina, Iwata, Nakao, Ikeda, Masashi, Darvasi, Ariel, Shifman, Sagiv, He, Lin, Duan, Jubao, Sanders, Alan R, Levinson, Douglas F, Gejman, Pablo V, Gejman, Pablo V, Sanders, Alan R, Duan, Jubao, Levinson, Douglas F, Buccola, Nancy G, Mowry, Bryan J, Freedman, Robert, Amin, Farooq, Black, Donald W, Silverman, Jeremy M, Byerley, William F, Cloninger, C Robert, Cichon, Sven, Nöthen, Markus M, Gill, Michael, Corvin, Aiden, Rujescu, Dan, Kirov, George ORCID: and Owen, Michael John ORCID: 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40 (9) , pp. 1053-1055. 10.1038/ng.201

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We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).

Item Type: Article
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 07 Dec 2022 07:28

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