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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Ferreira, Manuel A R, O'Donovan, Michael Conlon ORCID:, Meng, Yan A, Jones, Ian Richard ORCID:, Ruderfer, Douglas M., Jones, Lisa, Fan, Jinbo, Kirov, George ORCID:, Perlis, Roy H., Green, Elaine Karen, Smoller, Jordan W., Grozeva, Detelina ORCID:, Stone, Jennifer, Nikolov, Ivan, Chambert, Kimberly, Hamshere, Marian Lindsay ORCID:, Nimgaonkar, Vishwajit L., Escott-Price, Valentina ORCID:, Thase, Michael E., Caesar, Sian, Sachs, Gary S., Franklin, Jennifer, Gordon-Smith, Katherine, Ardlie, Kristin G, Gabriel, Stacey B, Fraser, Christine, Blumenstiel, Brendan, Defelice, Matthew, Breen, Gerome, Gill, Michael, Morris, Derek W., Elkin, Amanda, Muir, Walter J, McGhee, Kevin A., Williamson, Richard, MacIntyre, Donald J.., MacLean, Alan W., St Clair, David, Robinson, Michelle, Van Beck, Margaret, Pereira, Ana C. P., Kandaswamy, Radhika, McQuillin, Andrew, Collier, David A., Bass, Nicholas J., Young, Allan H, Lawrence, Jacob, Nicol Ferrier, I., Anjorin, Adebayo, Farmer, Anne, Curtis, David, Scolnick, Edward M., McGuffin, Peter, Daly, Mark J, Corvin, Aiden P, Holmans, Peter Alan ORCID:, Blackwood, Douglas H, Gurling, Hugh M, Owen, Michael John ORCID:, Purcell, Shaun M., Sklar, Pamela and Craddock, Nicholas John ORCID: 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40 (9) , pp. 1056-1058. 10.1038/ng.209

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To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 06 Nov 2022 14:34

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