Ferreira, Manuel A R, O'Donovan, Michael Conlon, Meng, Yan A, Jones, Ian Richard, Ruderfer, Douglas M., Jones, Lisa, Fan, Jinbo, Kirov, George, Perlis, Roy H., Green, Elaine Karen, Smoller, Jordan W., Grozeva, Detelina, Stone, Jennifer, Nikolov, Ivan, Chambert, Kimberly, Hamshere, Marian Lindsay, Nimgaonkar, Vishwajit L., Escott-Price, Valentina, Thase, Michael E., Caesar, Sian, Sachs, Gary S., Franklin, Jennifer, Gordon-Smith, Katherine, Ardlie, Kristin G, Gabriel, Stacey B, Fraser, Christine, Blumenstiel, Brendan, Defelice, Matthew, Breen, Gerome, Gill, Michael, Morris, Derek W., Elkin, Amanda, Muir, Walter J, McGhee, Kevin A., Williamson, Richard, MacIntyre, Donald J.., MacLean, Alan W., St Clair, David, Robinson, Michelle, Van Beck, Margaret, Pereira, Ana C. P., Kandaswamy, Radhika, McQuillin, Andrew, Collier, David A., Bass, Nicholas J., Young, Allan H, Lawrence, Jacob, Nicol Ferrier, I., Anjorin, Adebayo, Farmer, Anne, Curtis, David, Scolnick, Edward M., McGuffin, Peter, Daly, Mark J, Corvin, Aiden P, Holmans, Peter Alan, Blackwood, Douglas H, Gurling, Hugh M, Owen, Michael John, Purcell, Shaun M., Sklar, Pamela and Craddock, Nicholas John 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40 (9) , pp. 1056-1058. 10.1038/ng.209 |
Official URL: http://dx.doi.org/10.1038/ng.209
Abstract
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Neuroscience and Mental Health Research Institute (NMHRI) Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Systems Immunity Research Institute (SIURI) |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Publisher: | Nature Publishing Group |
ISSN: | 1061-4036 |
Last Modified: | 06 Feb 2022 11:37 |
URI: | https://orca.cardiff.ac.uk/id/eprint/29848 |
Citation Data
Cited 923 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |