Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia

Ikeda, Masashi, Yamanouchi, Yoshio, Kinoshita, Yoko, Kitajima, Tsuyoshi, Yoshimura, Reiji, Hashimoto, Shuji, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Nakamura, Jun, Ozaki, Norio and Iwata, Nakao 2008. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics 9 (10) , pp. 1437-1443. 10.2217/14622416.9.10.1437

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Abstract

AIMS: Abnormalities in dopaminergic and serotonergic transmission systems are thought to be involved in the pathophysiology of schizophrenia and the mechanisms underlying the therapeutic effects of antipsychotics. We conducted a pharmacogenetic study to evaluate whether variants in dopamine-related genes (DRD1-DRD5, AKT1 and GSK3beta) and serotonin receptor genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, HTR6 and HTR7) can be used to predict the efficacy of risperidone treatment for schizophrenia. MATERIALS & METHODS: A total of 120 first-episode neuroleptic-naive schizophrenia patients were treated with risperidone monotherapy for 8 weeks and clinical symptoms were evaluated by the Positive and Negative Syndrome Scale. RESULTS: Among the 30 variants that we examined, two SNPs in DRD2 (-241A>G [rs1799978] and TaqIA [rs1800497]) and two SNPs in AKT1 (AKT1-SNP1 [rs3803300] and AKT1-SNP5 [rs2494732]) were significant predictors of treatment response to risperidone. CONCLUSION: These data suggest that the SNPs in DRD2 and AKT1 may influence the treatment response to risperidone in schizophrenia patients.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Future Medicine
ISSN:	1462-2416
Last Modified:	20 Oct 2022 08:56
URI:	https://orca.cardiff.ac.uk/id/eprint/30142

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