Cerebral asymmetry in schizophrenia

Oertel-Knochel, Viola and Linden, David Edmund Johannes ORCID: https://orcid.org/0000-0002-5638-9292 2011. Cerebral asymmetry in schizophrenia. Neuroscientist 17 (5) , pp. 456-467. 10.1177/1073858410386493

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Abstract

The hemispheres of the human brain are anatomically and functionally asymmetric, and many cognitive and motor functions such as language and handedness are lateralized. This review examines anatomical, psychological, and physiological approaches to the understanding of separate hemispheric functions and their integration. The concept of hemispheric laterality plays a central role in current neuropsychological and pathophysiological models of schizophrenia. Reduced hemispheric asymmetry has also been reported for other mental disorders, for example, bipolar disorder. Recent research reflects an increasing interest in the molecular and population genetics of laterality and its potential link with animal models of schizophrenia. The authors review the principles of laterality and brain asymmetry and discuss the evidence for changes in asymmetry in schizophrenia and other mental disorders.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Lateralization ; Planum temporale ; Corpus callosum ; hemispheres ; Handedness
Publisher:	Sage
ISSN:	1073-8584
Last Modified:	20 Oct 2022 08:57
URI:	https://orca.cardiff.ac.uk/id/eprint/30171

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