Venturi, Vanessa, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Douek, Daniel C. and Davenport, Miles P. 2008. The molecular basis for public T-cell responses? Nature Reviews Immunology 8 (3) , pp. 231-238. 10.1038/nri2260 |
Abstract
Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are observed to dominate the response to the same antigenic epitope in multiple individuals, have long been a focus of immune T-cell repertoire studies. However, the mechanism that enables the survival of a specific TCR from the diverse repertoire produced in the thymus through to its involvement in a public immune response remains unclear. In this Opinion article, we propose that the frequency of production of T cells bearing different TCRs during recombination has an important role in the sharing of TCRs in an immune response, with variable levels of 'convergent recombination' driving production frequencies.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Systems Immunity Research Institute (SIURI) |
Subjects: | Q Science > QR Microbiology > QR180 Immunology |
Publisher: | Nature Publishing Group |
ISSN: | 1474-1733 |
Last Modified: | 20 Oct 2022 09:00 |
URI: | https://orca.cardiff.ac.uk/id/eprint/30329 |
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