Calcium-dependent and independent mechanisms in neutrophil activation: roles of kinase C, diacylglycerol, and unidentified intracellular messengers

Cooke, Eryl, Al-Mohanna, Futwan A. and Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X 1989. Calcium-dependent and independent mechanisms in neutrophil activation: roles of kinase C, diacylglycerol, and unidentified intracellular messengers. Hallett, Maurice Bartlett, ed. The Neutrophil: Cellular Biochemistry and Physiology, Boca Raton: CRC Press, pp. 219-242. (10.1201/9781351077200-9)

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Abstract

This chapter discusses the role of calcium and noncalcium intracellular messengers and their interactions. It explores the evidence of a role for kinase C in coupling stimulation to response. There is general agreement from the direct measurement of intracellular calcium ion (Ca2+) in neutrophils from a number of species that the resting intracellular Ca2+ concentration is approximately 0.1 µM. The existence of both Ca2+-dependent and possibly multiple Ca2+-independent mechanisms in the neutrophil may reflect the complexity of cellular events that must occur for these cells to successfully complete their task. Such a combination of intracellular messengers may enable control of a number of different cellular events and also control of the same event at different cellular locations. The normal functioning of the neutrophil depends upon the cell controlling not only the magnitude of a response, but also the cellular location at which the event occurs.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	CRC Press
Last Modified:	20 Nov 2025 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/30331

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