Cytoplasmic free calcium: measurement and manipulation in living cells

Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Dormer, Robert Leslie and Campbell, Anthony Keith 1990. Cytoplasmic free calcium: measurement and manipulation in living cells. Siddle, K. and Hutton, J. C., eds. Peptide Hormones: A Practical Approach, Practical Approach Series, vol. 71. Oxford: IRL Press, pp. 115-150. (10.1093/oso/9780199630707.003.0004)

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Abstract

The survival, specialized functions, and reproduction of eukaryotic animal and plant cells, and many prokaryotes, requires Ca2+ in the medium bathing the cells (1, 2, 3). In 1883, Sydney Ringer showed that the normal beating frog heart requires external Ca2+. The problem facing cell physiologists over the century since these pioneering experiments is how can one distinguish a ‘passive’ structural role for Ca2+ in a particular cell type from an ‘active’ regulatory one? In the latter case it is a change in free Ca2+ at a particular site within the cell which is responsible for initiating a response, for example cell movement, secretion or division.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	IRL Press
ISBN:	9780199630721
Last Modified:	20 Nov 2025 11:44
URI:	https://orca.cardiff.ac.uk/id/eprint/30413

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