Sanderson, David John, Good, Mark Andrew  ORCID: https://orcid.org/0000-0002-1824-1203, Seeburg, P. H., Sprengel, R., Rawlins, J. N. P. and Bannerman, D. M.
2008.
The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory.
Sossin, Wayne S., Lacaille, Jean-Claude, Castellucci, Vincent F. and Belleville, Sylvie, eds.
Essence of memory,
Progress in brain research,
vol. 169.
Amsterdam:
Elsevier,
pp. 159-178.
(10.1016/S0079-6123(07)00009-X)
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Abstract
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certain kinds of learning and memory in the mammalian brain. The expression of long-term potentiation (LTP) in the hippocampus, an experimental model of synaptic plasticity, requires the GluR-A subunit of the AMPA subtype of glutamate receptor. Genetically modified mice lacking the GluR-A subunit show normal acquisition of the standard, fixed-location, hidden-platform watermaze task, a spatial reference memory task that requires the hippocampus. In contrast, these mice are dramatically impaired on hippocampus-dependent, spatial working memory tasks, in which the spatial response of the animal is dependent on information in short-term memory. Taken together, these results argue for two distinct and independent spatial information processing mechanisms: (i) a GluR-A-independent associative learning mechanism through which a particular spatial response is gradually or incrementally strengthened, and which presumably underlies the acquisition of the classic watermaze paradigm and (ii) a GluR-A-dependent, non-associative, short-term memory trace which determines performance on spatial working memory tasks. These results are discussed in terms of Wagner's SOP model (1981).
| Item Type: | Book Section |
|---|---|
| Status: | Published |
| Schools: | Schools > Psychology |
| Uncontrolled Keywords: | glutamate receptors; long-term potentiation; hippocampus; spatial memory; associative learning; working memory |
| Additional Information: | Chapter 9 |
| Publisher: | Elsevier |
| ISBN: | 9780444531643 |
| ISSN: | 00796123 |
| Related URLs: | |
| Last Modified: | 20 Oct 2022 09:02 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/30450 |
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