The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory

Sanderson, David John, Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203, Seeburg, P. H., Sprengel, R., Rawlins, J. N. P. and Bannerman, D. M. 2008. The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory. Sossin, Wayne S., Lacaille, Jean-Claude, Castellucci, Vincent F. and Belleville, Sylvie, eds. Essence of memory, Progress in brain research, vol. 169. Amsterdam: Elsevier, pp. 159-178. (10.1016/S0079-6123(07)00009-X)

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Abstract

It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certain kinds of learning and memory in the mammalian brain. The expression of long-term potentiation (LTP) in the hippocampus, an experimental model of synaptic plasticity, requires the GluR-A subunit of the AMPA subtype of glutamate receptor. Genetically modified mice lacking the GluR-A subunit show normal acquisition of the standard, fixed-location, hidden-platform watermaze task, a spatial reference memory task that requires the hippocampus. In contrast, these mice are dramatically impaired on hippocampus-dependent, spatial working memory tasks, in which the spatial response of the animal is dependent on information in short-term memory. Taken together, these results argue for two distinct and independent spatial information processing mechanisms: (i) a GluR-A-independent associative learning mechanism through which a particular spatial response is gradually or incrementally strengthened, and which presumably underlies the acquisition of the classic watermaze paradigm and (ii) a GluR-A-dependent, non-associative, short-term memory trace which determines performance on spatial working memory tasks. These results are discussed in terms of Wagner's SOP model (1981).

Item Type:	Book Section
Status:	Published
Schools:	Psychology
Uncontrolled Keywords:	glutamate receptors; long-term potentiation; hippocampus; spatial memory; associative learning; working memory
Additional Information:	Chapter 9
Publisher:	Elsevier
ISBN:	9780444531643
ISSN:	00796123
Related URLs:	Publisher
Last Modified:	20 Oct 2022 09:02
URI:	https://orca.cardiff.ac.uk/id/eprint/30450

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