Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology

Palmer, Alice and Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203 2011. Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology. Biochemical Society Transactions 39 (4) , pp. 902-909. 10.1042/BST0390902

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Abstract

The present review summarizes converging evidence from animal and human studies that an early target of amyloid pathology is synaptic activity in the DG (dentate gyrus)/CA3 network. We briefly review the computational significance of the DG/CA3 network in the encoding of episodic memory and present new evidence that the CA3/DG pattern of activation is compromised in a mouse model of amyloid pathology. In addition, we present a new behavioural method to test the prediction that amyloid-related synaptic pathology will disrupt the formation of an integrated episodic-like (what, where and when) memory in mice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Alzheimer's disease (AD), amyloid β-peptide (Aβ), dentate gyrus (DG), episodic-like memory, hippocampal synaptic activity, pattern separation
Publisher:	Biochemical Society
ISSN:	0300-5127
Last Modified:	20 Oct 2022 09:02
URI:	https://orca.cardiff.ac.uk/id/eprint/30453

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