Orbito-frontal cortex is necessary for temporal context memory

Duarte, Audrey, Henson, Richard N., Knight, Robert T., Emery, Tina and Graham, Kim Samantha ORCID: https://orcid.org/0000-0002-1512-7667 2010. Orbito-frontal cortex is necessary for temporal context memory. Journal of Cognitive Neuroscience 22 (8) , pp. 1819-1831. 10.1162/jocn.2009.21316

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Abstract

Lesion and neuroimaging studies suggest that orbito-frontal cortex (OFC) supports temporal aspects of episodic memory. However, it is unclear whether OFC contributes to the encoding and/or retrieval of temporal context and whether it is selective for temporal relative to nontemporal (spatial) context memory. We addressed this issue with two complimentary studies: functional magnetic resonance imaging to measure OFC activity associated with successful temporal and spatial context memory during encoding and retrieval in healthy young participants, and a neuropsychological investigation to measure changes in spatial and temporal context memory in OFC lesion patients. Imaging results revealed that OFC contributed to encoding and retrieval of associations between objects and their temporal but not their spatial contexts. Consistent with this, OFC patients exhibited impairments in temporal but not spatial source memory accuracy. These results suggest that OFC plays a critical role in the formation and subsequent retrieval of temporal context.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Systems Immunity Research Institute (SIURI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0898-929X/ (accessed 26/02/2014).
Publisher:	MIT Press
ISSN:	0898-929x
Date of First Compliant Deposit:	30 March 2016
Last Modified:	20 May 2023 23:29
URI:	https://orca.cardiff.ac.uk/id/eprint/30460

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