Negative-pressure wound therapy: a snapshot of the evidence

Mendonca, Derick A, Papini, Remo and Price, Patricia Elaine 2006. Negative-pressure wound therapy: a snapshot of the evidence. International Wound Journal 3 (4) , pp. 261-271. 10.1111/j.1742-481X.2006.00266.x

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Abstract

Topical negative pressure (TNP) is a mode of therapy used to encourage wound healing. It can be used as a primary treatment for chronic/complex wounds or as an adjunct to surgery. Based on the evidence to date, the clinical effectiveness of negative-pressure therapy is still unclear. Although case reports and retrospective studies have demonstrated enhanced wound healing in acute/traumatic wounds, chronic wounds, infected wounds, wounds secondary to diabetes mellitus, sternal wounds and lower limb wounds, there are very few randomised controlled trials, with unclear results. The evidence is lacking for the use of TNP therapy for other indications to enhance wound healing such as patients with decubitus ulcers, diabetes and peripheral vascular disease and to improve skin graft take. There have been, as yet, no quality-of-life studies available for negative-pressure therapy. Despite this, the usage of TNP has increased. This review provides an overview of clinical studies using TNP and proposes avenues for further research to elucidate the exact mechanism of TNP, in addition to large randomised controlled clinical trials of patients undergoing this therapy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Schools > Healthcare Sciences
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Negative-pressure wound therapy ; Suction therapy ; Topical negative pressure ; Vacuum-assisted closure
Publisher:	Wiley-Blackwell
ISSN:	1742-4801
Last Modified:	04 Jun 2017 04:00
URI:	https://orca.cardiff.ac.uk/id/eprint/30637

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