Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex.

Ward-Robinson, Jasper, Whitt, Emma J., Horsley, Rachel R. and Jones, Peter M. 2010. Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex. Behavioral Neuroscience 124 (5) , pp. 587-599. 10.1037/a0020900

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Abstract

We report that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization. After surgery, rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B). Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B. Sham rats' generalization was greater when preexposure was to both A and B than when preexposure was to B only. That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing. Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations.

Item Type:	Article
Status:	Published
Schools:	Psychology
Subjects:	Q Science > QP Physiology
Uncontrolled Keywords:	perirhinal cortex; familiarity; novelty; generalization; recognition memory
Publisher:	American Psychological Association
ISSN:	1939-0084
Last Modified:	19 Mar 2016 22:55
URI:	https://orca.cardiff.ac.uk/id/eprint/31481

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