A commentary on the G2/M transition of the plant cell cycle

Francis, Dennis 2011. A commentary on the G2/M transition of the plant cell cycle. Annals of Botany 107 (7) , pp. 1065-1070. 10.1093/aob/mcr055

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Abstract

Background The complex events of mitosis rely on precise timing and on immaculate preparation for their success, but the G2/M transition in the plant cell cycle is currently steeped in controversy and alternative models. Scope In this brief review, the regulation of the G2/M transition in plants is commented on. The extent to which the G2/M transition is phosphoregulated by WEE1 kinase and CDC25 phosphatase, as exemplified in yeasts and animals, is discussed together with an alternative model that excludes these proteins from this transition. Arabidopsis T-DNA insertional lines for WEE1 and CDC25 that develop normally prompted the latter model. An argument is then presented that environmental stress is the norm for higher plants in temperate conditions. If so, the repressive role that WEE1 has under checkpoint conditions might be part of the normal cell cycle for many proliferative plant cells. Arabidopsis CDC25 can function as either a phosphatase or an arsenate reductase and recent evidence suggests that cdc25 knockouts are hypersensitive to hydroxyurea, a drug that induces the DNA-replication checkpoint. That other data show a null response of these knockouts to hydroxyurea leads to an airing of the controversy surrounding the enigmatic plant CDC25 at the G2/M transition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QK Botany
Uncontrolled Keywords:	Arabidopsis thaliana; cell-cycle checkpoints; CDC25 phosphatase; cyclin-dependent kinases; G2/M; WEE1 kinase
Publisher:	Oxford University Press
ISSN:	0305-7364
Last Modified:	31 Jul 2020 01:26
URI:	https://orca.cardiff.ac.uk/id/eprint/32200

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