Subcortical alterations in tissue microstructure adjacent to focal cortical dysplasia: Detection at diffusion-tensor MR imaging by using magnetoencephalographic dipole cluster localization

Widjaja, Elysa, Zarei Mahmoodabadi, Siria, Otsubo, Hiroshi, Snead, O. Carter, Holowka, Stephanie, Bells, Sonya ORCID: https://orcid.org/0000-0001-8688-1571 and Raybaud, Charles 2009. Subcortical alterations in tissue microstructure adjacent to focal cortical dysplasia: Detection at diffusion-tensor MR imaging by using magnetoencephalographic dipole cluster localization. Radiology 251 (1) , pp. 206-215. 10.1148/radiol.2511081092

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Abstract

Purpose: To determine whether changes at diffusion-tensor magnetic resonance (MR) imaging were present in children with intractable epilepsy and focal cortical dysplasia (FCD) in (a) subcortical white matter subjacent to MR imaging–visible areas of FCD, (b) subcortical white matter beyond the MR imaging–visible abnormality but subjacent to a magnetoencephalographic (MEG) dipole cluster, and (c) deep white matter tracts. Materials and Methods: The study protocol had institutional research ethics board approval, and written informed consent was obtained. Fifteen children with FCD and intractable epilepsy (mean age, 11.6 years; range, 3.6–18.3 years) underwent diffusion-tensor MR imaging and MEG. Regions of interest were placed in (a) the subcortical white matter subjacent to the MR imaging–visible abnormality, as well as the contralateral side; (b) the subcortical white matter beyond the MR imaging–visible abnormality but subjacent to a MEG dipole cluster, as well as the contralateral side; and (c) deep white matter tracts projecting to or from the MR imaging–visible FCD, as well as the contralateral side. Fractional anisotropy (FA), mean diffusivity, and eigenvalues (λ1, λ2, λ3) were evaluated. Results: Eleven of 15 children had MEG dipole clusters, and four children had MEG scatter. There were significant differences in FA, mean diffusivity, λ2, and λ3 of the subcortical white matter subjacent to the MR imaging–visible FCD (P < .001 for all), as well as that beyond the MR imaging–visible FCD but subjacent to a MEG dipole cluster (P = .001, P = .036, P < .001, and P = .002, respectively), compared with the contralateral side. There were also significant differences in FA (P < .001), mean diffusivity (P = .008), λ2 (P < .001), and λ3 (P = .001) of the deep white matter tracts projecting to or from the MR imaging–visible FCD compared with the contralateral side. Conclusion: With use of MEG dipole clusters to localize the epileptogenic zone, diffusion-tensor imaging can help identify alterations in tissue microstructure beyond the MR imaging–visible FCD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Publisher:	Radiological Society of North America
ISSN:	0033-8419
Last Modified:	20 Oct 2022 09:32
URI:	https://orca.cardiff.ac.uk/id/eprint/32383

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