Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats

Jenkins, Trisha Anne, Dias, Rebecca, Amin, Eman, Brown, Malcolm W. and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2002. Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats. Journal of Neuroscience 22 (12) , pp. 5230-5238.

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Abstract

Activity of the immediate early gene c-fos was compared in rats with neurotoxic lesions of the anterior thalamic nuclei and in surgical controls. Fos levels were measured after rats had been placed in a novel room and allowed to run up and down preselected arms of a radial maze. An additional control group showed that in normal rats, this exposure to a novel room leads to a Fos increase in a number of structures, including the anterior thalamic nuclei and hippocampus. In contrast, rats with anterior thalamic lesions were found to have significantly less Fos-positive cells in an array of sites, including the hippocampus (dorsal and ventral), retrosplenial cortex, anterior cingulate cortex, and prelimbic cortex. These results show that anterior thalamic lesions disrupt multiple limbic brain regions, producing hypoactivity in sites associated in rats with spatial memory. Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QL Zoology
Uncontrolled Keywords:	amnesia, hippocampus, immediate early genes, limbic cortices, rat, spatial memory, thalamus
Additional Information:	: “Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.”http://creativecommons.org/licenses/ See: http://www.jneurosci.org/site/misc/ifa_policies.xhtml
Publisher:	Societzy for Neuroscience
ISSN:	0270-6474
Last Modified:	08 May 2023 05:48
URI:	https://orca.cardiff.ac.uk/id/eprint/3253

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